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Glycoprotein 100, gp100 or (Melanocyte protein PMEL ) is 661 amino acids long and is a type I transmembrane glycoprotein enriched in melanosomes, which are the melanin-producing organelles in melanocytes. This protein is involved in melanosome maturation. The gp100 protein is a melanoma antigen i.e. a tumor-associated antigen. Short fragments of it have been used to develop the gp100 cancer vaccine which is or contains gp100:209-217(210M).〔http://www.cancer.gov/drugdictionary/?CdrID=476335〕 Hydrophilic recombinant gp100 protein (HR-gp100) has been topically applied on human intact skin in vitro, and used as a vaccine in a mouse model. It was demonstrated that HR-gp100 permeates into human skin, and is processed and presented by human dendritic cells. In the mouse model, an HR-gp100-based vaccine triggered antigen-specific T cell responses, as shown by proliferation assays, ELISA and intracellular staining for IFN-γ. ==References== * 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Glycoprotein 100」の詳細全文を読む スポンサード リンク
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